{"id":4268256,"date":"2021-04-01T10:10:24","date_gmt":"2021-04-01T08:10:24","guid":{"rendered":"https:\/\/www.deptagency.com\/?post_type=case&#038;p=4268256"},"modified":"2025-12-08T11:16:17","modified_gmt":"2025-12-08T09:16:17","slug":"building-a-platform-to-accelerate-kidney-disease-research","status":"publish","type":"case","link":"https:\/\/www.deptagency.com\/en-au\/case\/building-a-platform-to-accelerate-kidney-disease-research\/","title":{"rendered":"Building a platform to accelerate kidney disease research"},"content":{"rendered":"<section class=\"block-post-header block-post-header__theme--white\">\n\t<button class=\"btn btn__color--richBlack block-post-header__btn\" onclick=window.history.back()>\n\t\t\t<span class=\"btn__icon\">\n\t\t\t<i class=\"icon icon__size--medium-variable icon__arrow-left-circle\">\n\t<svg xmlns='http:\/\/www.w3.org\/2000\/svg' width='24' height='24' fill='none' viewBox='0 0 24 24'><g class='symbol'><path stroke='currentColor' stroke-miterlimit='10' stroke-width='1.5' d='M12.479 6.74L6.739 12l5.74 5.26M7.217 12H17.74'\/><circle cx='12' cy='12' r='11' stroke='currentColor' stroke-miterlimit='10' stroke-width='1.5'\/><\/g><path class='symbol-hover' fill='currentColor' fill-rule='evenodd' d='M1 12c0 6.075 4.925 11 11 11s11-4.925 11-11S18.075 1 12 1 1 5.925 1 12zm5.233.553l5.739 5.26 1.013-1.105-4.318-3.958h9.072v-1.5H8.667l4.318-3.958-1.013-1.106-5.74 5.261L5.63 12l.604.553z' clip-rule='evenodd'\/><\/svg><\/i>\t\t<\/span>\n\t\n\t<\/button>\n\t<h1 class=\"heading heading__size--xl heading__align--left block-post-header__heading\">\n\t\t\tBuilding a platform to accelerate kidney disease research\t<\/h1><\/section>\n\n<div class=\"intro-text block-intro-text__intro-text intro-text__background-color--heather\" data-position=\"top left\">\n\t<div class=\"intro-text__content\" >\n\t\t<h2 class=\"heading heading__color--richBlack heading__size--s heading__align--left intro-text__heading\">\n\t\t\tGoldfinch Bio is a leading biotech company that is conducting critical research to discover precision therapies for patients with kidney disease. They are collecting samples from affected patients, sequencing them, and enrolling them into a Kidney Genome Atlas (KGA), to build a data set large enough that the company can use statistical methods to identify potential drug targets with genetic evidence. Together with DEPT\u00ae, we built a dynamic web-based application that allowed them to surface all of the data they were collecting and producing as part of the KGA. This allows their researchers to simplify their complex workflows and create efficient data visualisations which enables them to do better work, faster.\t<\/h2>\t<\/div>\n<\/div>\n\n<div class=\"block-panel-with-rich-text\">\n\t<div class=\"block-panel-with-rich-text__left block-panel-with-rich-text__left--richBlack\">\n\t\t<h2 class=\"heading heading__size--xl heading__align--left block-panel-with-rich-text__heading\">\n\t\t\tAccelerating the company\u2019s growth to further kidney disease research\t<\/h2>\t<\/div>\n\n\t<div class=\"block-panel-with-rich-text__right block-panel-with-rich-text__right--white\">\n\t\t<div class=\"block-panel-with-rich-text__right-content block-panel-with-rich-text__right-content--white\">\n\t\t\t\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">Chronic kidney disease (CKD) is a growing health epidemic affecting an estimated 37 million people in the U.S. Given this large number, there is a fast-growing need for new treatment options to help this underserved patient population.\u00a0<a href=\"https:\/\/www.goldfinchbio.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Goldfinch Bio<\/a>\u00a0is focused on discovering and developing precision therapies for patients with kidney disease. We partnered to accelerate the company\u2019s innovative approach to kidney disease treatment by automating the processing of large scale genomic and longitudinal patient data, streamlining complex workflows while reducing repetitive tasks.<\/p><\/div><\/div>\n\t\t<\/div>\n\n\t\t<\/div>\n<\/div>\n\n<div\n\tclass=\"flyout-drawer js-flyout-drawer flyout-drawer__position--right\"\n\tdata-trigger=\"#block-panel-with-rich-text-9b8216ebb027fd1ac1e77b112a16ed8a\"\n\tdata-instant-open=\"false\"\n>\n\t<div class=\"flyout-drawer__left-mobile-backplate\"><\/div>\n\t<div class=\"flyout-drawer__left-backplate\"><\/div>\n\n\t\t<div class=\"flyout-drawer__left\"><\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__close cta-button__color--white cta-button__style--text-and-icon js-drawer-close has-flipped-icon\" aria-label=\"Close\" >\n\t<svg width='21' height='21' viewBox='0 0 21 21' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='10.5' cy='10.5' r='9.5' transform='rotate(-90 10.5 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js-pardot-forms-label\"\n\t\t\t\t\t>\n\t\t\t\t\t\t<input\n\t\t\t\t\t\t\ttype=\"radio\"\n\t\t\t\t\t\t\tname=\"form-pick\"\n\t\t\t\t\t\t\tid=\"block-panel-with-rich-text-pardot-forms-555fcdadbe255e010e40aafd2657d742-3\"\n\t\t\t\t\t\t\tclass=\"pardot-forms__input block-panel-with-rich-text__input js-pardot-forms-input\"\n\t\t\t\t\t\t\tvalue=\"https:\/\/www2.deptagency.com\/l\/321011\/2023-07-28\/2f49nnz\"\n\t\t\t\t\t\t\/>\n\t\t\t\t\t\t<span class=\"pardot-forms__form-title block-panel-with-rich-text__form-title\">\n\t\t\t\t\t\t\tWorking at DEPT\u00ae\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t<\/form>\n\t\t<iframe\n\t\tdata-initial-src=\"\"\n\t\tclass=\"pardot-forms__embed block-panel-with-rich-text__embed js-pardot-forms-embed\"\n\t\ttype=\"text\/html\"\n\t><\/iframe>\n\t<div class=\"loader pardot-forms__loader loader__color--hanPurple js-pardot-forms-loader\">\n\t<div class=\"loader__first\"><\/div>\n\t<div class=\"loader__second\"><\/div>\n<\/div><\/div>\t<\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__back cta-button__color--onyxGrey cta-button__style--text-and-icon js-drawer-back has-small-icon\" aria-label=\"Back\" >\n\t<svg width='41' height='41' viewBox='0 0 41 41' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' stroke='var(--dept-button-icon-outline-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><circle class='icon-backplate' cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' fill='var(--dept-button-icon-backplate-color)' fill-opacity='1'\/><path class='icon-center' d='M21.174 30 11 20.674l10.174-9.326m-9.326 9.328H30.5' stroke='var(--dept-button-icon-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><\/svg>\n\t\t\t<span>\n\t\t\tBack\t\t<\/span>\n\t\n<\/button><\/div>\n\n<div class=\"call-to-action block-call-to-action__call-to-action call-to-action__background-color--white\">\n\n\t<p class=\"paragraph paragraph__color--richBlack paragraph__align--center call-to-action__paragraph\">Automating the processing of large scale patient data<\/p>\n<\/div>\n\n<div class=\"block-panel-with-rich-text\">\n\t<div class=\"block-panel-with-rich-text__left block-panel-with-rich-text__left--richBlack\">\n\t\t<h2 class=\"heading heading__size--xl heading__align--left block-panel-with-rich-text__heading\">\n\t\t\tCreating a holistic, interconnected system\t<\/h2>\t<\/div>\n\n\t<div class=\"block-panel-with-rich-text__right block-panel-with-rich-text__right--white\">\n\t\t<div class=\"block-panel-with-rich-text__right-content block-panel-with-rich-text__right-content--white\">\n\t\t\t\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">Goldfinch researchers and computational biologists were operating under a highly complex, disconnected workflow in order to be able to receive, process, and analyse a massive amount of data coming from various sources, such as biopsies, tests, patient samples, etc. Goldfinch had multiple systems and software suites being used to look at the data, compare cohorts, and test compounds in the lab. The company needed a way to connect its systems to be able to quickly go from curating, to examining, to validating their data.\u00a0<\/p><\/div><\/div>\n\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">To solve this problem, we started off with a\u00a0<a href=\"https:\/\/www.deptagency.com\/en-gb\/story\/bringing-digital-products-to-life-with-design-sprints\/\" target=\"_blank\" rel=\"noreferrer noopener\">design sprint<\/a>\u00a0and rapidly moved into development, while conducting extensive user research with Goldfinch\u2019s biologists and medical researchers. We did this to better understand their workflow and what they needed from the data. This enabled us to clearly articulate the workflows that were needed for each team. We moved toward a vision of creating a software platform that could connect disparate workflows with visualisations that would make each teams\u2019 work quicker.\u00a0<\/p><\/div><\/div>\n\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">We quickly built a prototype of the platform so we could begin testing and iterating based on feedback from the research team. We learned that the interconnectedness of the platform was enabling the researchers and the biologists to take data, examine it, and be confident in what they found, all in a much more efficient way. This was crucial, as it allowed the team to move faster when deciding which gene mutations they wanted to pursue further research on. From there, the prototype evolved into a powerful software application with a tremendous set of features and visualisations for the Goldfinch team.<\/p><\/div><\/div>\n\t\t<\/div>\n\n\t\t<\/div>\n<\/div>\n\n<div\n\tclass=\"flyout-drawer js-flyout-drawer flyout-drawer__position--right\"\n\tdata-trigger=\"#block-panel-with-rich-text-a3416b35125e4415c9e9a059583dc273\"\n\tdata-instant-open=\"false\"\n>\n\t<div class=\"flyout-drawer__left-mobile-backplate\"><\/div>\n\t<div class=\"flyout-drawer__left-backplate\"><\/div>\n\n\t\t<div class=\"flyout-drawer__left\"><\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__close cta-button__color--white cta-button__style--text-and-icon js-drawer-close has-flipped-icon\" aria-label=\"Close\" >\n\t<svg width='21' height='21' viewBox='0 0 21 21' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='10.5' cy='10.5' r='9.5' transform='rotate(-90 10.5 10.5)' stroke='var(--dept-button-icon-outline-color)' stroke-width='1.3' 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js-pardot-forms-label\"\n\t\t\t\t\t>\n\t\t\t\t\t\t<input\n\t\t\t\t\t\t\ttype=\"radio\"\n\t\t\t\t\t\t\tname=\"form-pick\"\n\t\t\t\t\t\t\tid=\"block-panel-with-rich-text-pardot-forms-a02bd01aba37d89705e7ab2bf3c017cf-3\"\n\t\t\t\t\t\t\tclass=\"pardot-forms__input block-panel-with-rich-text__input js-pardot-forms-input\"\n\t\t\t\t\t\t\tvalue=\"https:\/\/www2.deptagency.com\/l\/321011\/2023-07-28\/2f49nnz\"\n\t\t\t\t\t\t\/>\n\t\t\t\t\t\t<span class=\"pardot-forms__form-title block-panel-with-rich-text__form-title\">\n\t\t\t\t\t\t\tWorking at DEPT\u00ae\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/label>\n\t\t\t\t\t\t\t<\/form>\n\t\t<iframe\n\t\tdata-initial-src=\"\"\n\t\tclass=\"pardot-forms__embed block-panel-with-rich-text__embed js-pardot-forms-embed\"\n\t\ttype=\"text\/html\"\n\t><\/iframe>\n\t<div class=\"loader pardot-forms__loader loader__color--hanPurple js-pardot-forms-loader\">\n\t<div class=\"loader__first\"><\/div>\n\t<div class=\"loader__second\"><\/div>\n<\/div><\/div>\t<\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__back cta-button__color--onyxGrey cta-button__style--text-and-icon js-drawer-back has-small-icon\" aria-label=\"Back\" >\n\t<svg width='41' height='41' viewBox='0 0 41 41' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' stroke='var(--dept-button-icon-outline-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><circle class='icon-backplate' cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' fill='var(--dept-button-icon-backplate-color)' fill-opacity='1'\/><path class='icon-center' d='M21.174 30 11 20.674l10.174-9.326m-9.326 9.328H30.5' stroke='var(--dept-button-icon-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><\/svg>\n\t\t\t<span>\n\t\t\tBack\t\t<\/span>\n\t\n<\/button><\/div>\n\n<div class=\"block-panel-with-rich-text\">\n\t<div class=\"block-panel-with-rich-text__left block-panel-with-rich-text__left--richBlack\">\n\t\t<h2 class=\"heading heading__size--xl heading__align--left block-panel-with-rich-text__heading\">\n\t\t\tThree environments wrapped in one application\t<\/h2>\t<\/div>\n\n\t<div class=\"block-panel-with-rich-text__right block-panel-with-rich-text__right--white\">\n\t\t<div class=\"block-panel-with-rich-text__right-content block-panel-with-rich-text__right-content--white\">\n\t\t\t\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">The result? Three distinct environments for development, staging, and production of the overall application. We used a simple storage service (Amazon S3) that talks to an API which is built on a mostly serverless stack in AWS.<\/p><\/div><\/div>\n\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">Backing the API is an event-driven pipeline that produces everything the app needs on-demand. This means that when someone uploads a new study from the app, the pipeline is kicked off. The data presented to users is derived from petabytes of raw data. This data is processed, refined, and distilled to a much smaller, more manageable data set. It is also supplemented, enriched and annotated with public data to give the end-users everything they need to better understand the genetic drivers of kidney disease. It helps to identify potential new drug targets that will help these patients who desperately need new treatments. In short, this solution has enabled the company\u2019s various researchers to work in a more efficient manner while unearthing important patterns that will inform further research.<\/p><\/div><\/div>\n\t\t<\/div>\n\n\t\t<\/div>\n<\/div>\n\n<div\n\tclass=\"flyout-drawer js-flyout-drawer flyout-drawer__position--right\"\n\tdata-trigger=\"#block-panel-with-rich-text-7fc4672875dfdd34a83a795f41fc8b2e\"\n\tdata-instant-open=\"false\"\n>\n\t<div class=\"flyout-drawer__left-mobile-backplate\"><\/div>\n\t<div class=\"flyout-drawer__left-backplate\"><\/div>\n\n\t\t<div class=\"flyout-drawer__left\"><\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__close cta-button__color--white cta-button__style--text-and-icon js-drawer-close has-flipped-icon\" aria-label=\"Close\" >\n\t<svg width='21' height='21' viewBox='0 0 21 21' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='10.5' cy='10.5' r='9.5' transform='rotate(-90 10.5 10.5)' stroke='var(--dept-button-icon-outline-color)' 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class=\"loader__second\"><\/div>\n<\/div><\/div>\t<\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__back cta-button__color--onyxGrey cta-button__style--text-and-icon js-drawer-back has-small-icon\" aria-label=\"Back\" >\n\t<svg width='41' height='41' viewBox='0 0 41 41' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' stroke='var(--dept-button-icon-outline-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><circle class='icon-backplate' cx='20.5' cy='20.5' r='19.5' transform='rotate(-90 20.5 20.5)' fill='var(--dept-button-icon-backplate-color)' fill-opacity='1'\/><path class='icon-center' d='M21.174 30 11 20.674l10.174-9.326m-9.326 9.328H30.5' stroke='var(--dept-button-icon-color)' stroke-width='1.3' stroke-miterlimit='10' fill='none'\/><\/svg>\n\t\t\t<span>\n\t\t\tBack\t\t<\/span>\n\t\n<\/button><\/div>\n\n<div class=\"block-panel-with-rich-text\">\n\t<div class=\"block-panel-with-rich-text__left block-panel-with-rich-text__left--richBlack\">\n\t\t<h2 class=\"heading heading__size--xl heading__align--left block-panel-with-rich-text__heading\">\n\t\t\tEnhancing the company\u2019s innovative approach\t<\/h2>\t<\/div>\n\n\t<div class=\"block-panel-with-rich-text__right block-panel-with-rich-text__right--white\">\n\t\t<div class=\"block-panel-with-rich-text__right-content block-panel-with-rich-text__right-content--white\">\n\t\t\t\n<div class='block-panel-with-rich-text__item'><div class='block-panel-with-rich-text__item-inner'><p class=\"paragraph paragraph__size--default paragraph__align--left block-paragraph__paragraph\">Goldfinch\u2019s vision is to eradicate kidney disease through precision medicine. The ability to evaluate large amounts of data, automate processes with technology, and ultimately speed up their workflow is a big deal in reaching that vision. With our help, the company is able to work more efficiently by doing less manual work. They can easily see complex data visualisations through the platform that would have previously required third-party tools and manual efforts to pull together. These visualisations allow the team to unearth important patterns that will inform further research and, ultimately, treatment.\u00a0<\/p><\/div><\/div>\n\t\t<\/div>\n\n\t\t<\/div>\n<\/div>\n\n<div\n\tclass=\"flyout-drawer js-flyout-drawer flyout-drawer__position--right\"\n\tdata-trigger=\"#block-panel-with-rich-text-2c955e5cfdbd1fbcc39a6a0045899716\"\n\tdata-instant-open=\"false\"\n>\n\t<div class=\"flyout-drawer__left-mobile-backplate\"><\/div>\n\t<div class=\"flyout-drawer__left-backplate\"><\/div>\n\n\t\t<div class=\"flyout-drawer__left\"><\/div>\n\n\t<button\tclass=\"cta-button flyout-drawer__close cta-button__color--white cta-button__style--text-and-icon js-drawer-close has-flipped-icon\" aria-label=\"Close\" >\n\t<svg width='21' height='21' viewBox='0 0 21 21' fill='none' xmlns='http:\/\/www.w3.org\/2000\/svg'><circle cx='10.5' cy='10.5' r='9.5' transform='rotate(-90 10.5 10.5)' stroke='var(--dept-button-icon-outline-color)' stroke-width='1.3' stroke-miterlimit='10' 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class=\"block-get-in-touch__column block-get-in-touch__column--left block-get-in-touch__column--richBlack\">\n\t\t<h2 class=\"heading heading__color--white heading__size--xl heading__align--left block-get-in-touch__heading\">\n\t\t\tQuestions?\t<\/h2>\t<\/div>\n\n\t<div class=\"block-get-in-touch__column block-get-in-touch__column--right block-get-in-touch__column--white\">\n\t<div\n\t\tclass=\"image-wrap block-get-in-touch__image-wrap\"\n\t\tdata-align=\"top center\"\n\t\t\t>\n\n\t\t\t<div style=\"background-image:url(https:\/\/www.deptagency.com\/wp-content\/uploads\/2021\/05\/Ashley_Streb.jpg)\" class=\"image image--bg block-get-in-touch__image\" ><\/div>\n\t\n\t<\/div>\t\t\t<div class=\"block-get-in-touch__specialist\">\n\t\t\t\t<p class=\"heading heading__color--richBlack heading__size--xxs heading__align--left block-get-in-touch__subtitle\">\n\t\t\tChief Client Officer, DEPT\u00ae Americas\t<\/p><h3 class=\"heading heading__color--richBlack heading__size--m heading__align--left 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